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抗惊恐障碍药物的临床研究进展

Clinical Research Progress of Anti-panic Disorder Drugs

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【作者】 许丽华胡全戴海斌

【Author】 XU Li-hua;HU Quan;DAI Hai-bin;College of Pharmacy Science,Hangzhou Normal University;Hangzhou Key Laboratory of Neurobiology and Department of Pharmacology,School of Basic Medicine,Hangzhou Normal University;Second Affiliated Hospital,Zhejiang University School of Medicine;

【机构】 杭州师范大学药学院杭州师范大学医学神经生物学市级重点实验室,基础医学部药理学教研室浙江大学医学院附属第二医院

【摘要】 本文综述了临床上用于治疗惊恐障碍的相关药物,评价并比较这些药物的疗效、不良反应及差异。结果发现,在当前选择性5-羟色胺再摄取抑制剂西酞普兰、依他普仑、氟伏沙明、氟西汀、帕罗西汀、舍曲林,5-羟色胺和去甲肾上腺素再摄取抑制剂、三环抗抑郁药和苯二氮艹卓类为治疗惊恐障碍的有效药物。另外,β受体阻断剂、抗惊厥药、孕激素、肌醇、丁螺环酮等在惊恐障碍的治疗中也有使用。因此,当前惊恐障碍药物的临床研究很好的反应了这些药物的作用和差异,这有助于临床医护工作者有效的选择药物。

【Abstract】 This paper reviewed the clinical drugs used in the treatment of panic disorder(PD),evaluated and compared the efficacy,adverse reactions and differences of these drugs. It was found that the selective serotonin reuptake inhibitors including citalopram,escitalopram,fluvoxamine,fluoxetine,paroxetine and sertraline,the serotonin,noradrenaline reuptake inhibitors,the tricyclic antidepressants and benzodiazepines are effective in panic disorder treatment currently. And β-receptor blockers,anti-seizure medication,progesterone,inositol,buspirone are also found in the treatment of panic disorder. Thus,the clinical researches of panic disorder proved the role and differences between these drugs,which could help the clinical medical worker to select effectively.

  • 【文献出处】 海峡药学 ,Strait Pharmaceutical Journal , 编辑部邮箱 ,2015年04期
  • 【分类号】R749.7
  • 【被引频次】4
  • 【下载频次】213
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