【摘要】 目的探讨托特罗定干预输尿管双J管留置后膀胱过度活动症的疗效及安全性。方法 2014年4~12月在我院泌尿外科住院术后输尿管留置双J管患者126例,随机分成两组,每组各63例。观察组术后拔除尿管日开始口服托特罗定2 mg/d连续6周至拔除双J管;对照组无相关辅助治疗。两组患者均于术前1 d及术后6周拔除双J管前完成OABSS问卷表,比较其带管期间尿急评分和OABSS评分情况,记录观察组治疗期间药物不良反应发生情况。结果观察组尿急评分为(1.6±0.8)分,对照组为(3.5±1.6)分,两组比较差异具有统计学意义(P<0.01);治疗组OABSS评分为(3.4±1.3)分,对照组为(8.2±3.6)分,两组比较差异具有统计学意义(P<0.01)。观察组治疗期间药物总不良反应发生率为14.3%。结论托特罗定干预输尿管双J管留置后膀胱过度活动症安全、有效,可用于输尿管双J管留置术后患者,改善生活质量。更多还原

【Abstract】 Objective To investigate the curative effect and safety of Tolterodine intervention for overactive bladder after retaining double J tuble in ureter. Methods One hundred and twenty-six patients in Department of Urology between April 2014 and December 2014 with retained double J tube in ureter were randomly divided into two groups: control group(n=63) and treatment group(n=63). Patients in the treatment group after catheter removal day were given oral Tolterodine 2 mg per day consecutively for 6 weeks until the removal of double J tube. Patients in the control group did not receive any relevant auxiliary treatment. The urgency score and overactive bladder symptom score(OABSS, investigated one day before surgery and 6 weeks after surgery) were compared between the two groups, and the adverse reactions in the treatment group were recorded. Results The urgency score in treatment group and in the control group were(1.6±0.8) and(3.5±1.6), respectively, with statistically significant differences between the two groups(P<0.01). The OABSS score in treatment group and in the control group were(3.4 ± 1.3) and(8.2 ± 3.66), respectively, and there was statistically significant differences(P<0.01). Conclusion Tolterodine intervention for overactive bladder after retaining double J tuble is safe and effective, which can help improve the quality of life for patients.更多还原