【摘要】 目的:探讨结肠脾曲远端结直肠癌中枢方向D3术式的必要性。方法:对2007-2008年收治的39例结肠脾曲远瑞结直肠癌患者中枢方向淋巴结转移及CK20免疫组化淋巴结微转移状况及生存等因素进行分析。结果:10.26%(4/39)的患者发生了N3站淋巴结转移;17.95%(7/39)的患者发生了N3站淋巴结微转移;肿瘤浸润肠腔>1/3周、合并原发灶外癌结节、Dukes分期越高的患者易于出现高站别淋巴结微转移,发生高站别淋巴结微转移的患者预后不良。结论:CK20免疫组化淋巴结微转移检测简便、易行,优于HE染色;结直肠癌中枢方向行D3术式有临床意义。更多还原

【Abstract】 Objective: To investigate the necessity for D3 resection in central direction for patients with colorectal cancer beneath the splenic flexure. Methods: Analyze lymph nodes metastasis and CK20 immunehistochemistry positive lymph nodes micro-metastasis in 39 patients with colorectal cancer which is beneath the splenic flexure.Results: 10.26%( 4 / 39) of the patients presented N3 stage lymph nodes metastasis; 17.25%( 7 / 39)of the patients presented N3 stage lymph nodes micro-metastasis; tumor invasion circle proportion in intestine cavity more than 1 / 3,with tumor nodes outside the tumor,higher stage of Dukes classification,thse patients were more prone to present highly staged lymph nodes micro-metastasis,which indicated poorer prognosis.Conclusion:CK20 immune-histochemistry assay which was used to detect lymph nodes micro-metastasis was more convinient and feasible than traditional H-E staining,to perform D3 resection in colorectal cancer which is beneath the splenic flexure was of clinical siginificance.更多还原