【摘要】 目的研究首都医科大学附属北京地坛医院乙型肝炎肝硬化住院患者的并发症、合并症及死亡的相关危险因素。方法分别回顾性分析本院2008年1月至2010年12月2568例和2011年1月至2014年9月3008例乙型肝炎肝硬化住院患者的相关资料。结果发现乙型肝炎肝硬化并发症发病率最高为原发性肝癌,不同时期比较发现发病率呈上升趋势(P=0.000),其余并发症如腹水、上消化道出血、自发性细菌性腹膜炎、肝性脑病、肝肾综合征发病率呈下降趋势(P=0.000)。2型糖尿病、高血压等合并症发病率前后比较无统计学差异(P=0.399,P=0.089)。除自发性细菌性腹膜炎外,肺部感染是肝硬化住院患者最易发的感染。对不同时期死亡的相关危险因素进行多元回归分析,肝癌、自发性细菌性腹膜炎、肝性脑病、肝肾综合征和上消化道出血均与病死显著相关(P=0.000)。结论原发性肝癌仍然是乙型肝炎肝硬化最常见并发症,也是乙型肝炎肝硬化最主要的病死原因,病死患者均伴发多种并发症。更多还原

【Abstract】 Objcetive To analyze the associated complications and the causes of death of hepatitis B virus related cirrhosis patients. Methods The data of 2568 patients from January 2008 to December 2010 and 3008 patients from January 2011 to September 2014, hospitalized in Beijing Ditan Hospital, Capital Medical University, were retrospective reviewed respectively. Results Among all the hepatitis B virus(HBV) related cirrhosis patients, the highest incidence of complication was primary hepatocellular carcinoma(HCC) and it showed an ascending trend in recent years(P = 0.000). The incidence of other complications, including ascites, spontaneous bacterial peritonitis(SBP), upper gastrointestinal bleeding, hepatic encephalopathy(HE) and hepatorenal syndrome(HRS) were reduced(P = 0.000). No significant difference between the incidence of type 2 diabetes and hypertension(P = 0.399,P = 0.089). Apart from SBP, pneumonia was the most frequent type of infection. Conclusions HCC is still the most common complication and the predominant cause of HBV related cirrhosis. A variety of complications coexist in all death patients.更多还原