目的:观察甘草干姜汤对变应性鼻炎大鼠外周血中γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)的表达及鼻黏膜组织的影响。方法:120只大鼠随机分为正常组、甘草干姜汤组、模型组及西药组4组,后3组用卵清蛋白(AVO)制作变应性鼻炎动物模型,分别给予甘草干姜汤2~2.5 m L/只、西替利嗪溶液2~2.5 m L/只、生理盐水2~2.5 m L/只灌胃(模型组及对照组),每天1次;每组大鼠分别在灌胃10、20及30 d时处死10只,检测大鼠血清中IFN-γ和IL-4水平,同时观察各组大鼠各时点的行为学和鼻黏膜组织学变化。结果:灌胃10 d,甘草干姜汤组和西药组与模型组大鼠行为学表现无明显差异(P>0.05),但与正常组存在明显差异(P<0.01);灌胃20 d,甘草干姜汤组和西药组大鼠与模型组和正常组均有明显的差异(P<0.01);灌胃30 d,甘草干姜汤组和西药组行为学变化接近正常组(P>0.05);甘草干姜汤组和西药组灌胃10和20 d时,血清中IFN-γ、IL-4水平与正常组、模型组均有明显差异(P<0.01);灌胃30 d,甘草干姜汤组、西药组IFN-γ和IL-4与模型组比较,分别有明显升高和下降(P<...
【英文摘要】
Objective: To observe the impact of licorice and dried ginger on peripheral blood levels ofγ-interferon( IFN-γ) and interleukin-4( IL-4) as well as nasal tissue of allergic rhinitis rats. Methods: A total of 120 rats were randomly divided into four groups: the normal control group( group C),licorice and dried ginger group( group L),model group( group M),and western medicine control group( group W). Rats in the latter three groups were given ovalbumin( OVA) to establish allergic rhinitis model and were given...