【摘要】 目的探讨瞬时弹性扫描技术联合低拷贝内标定量在无症状慢性HBV感染者的临床效果。方法选取2015年3~9月,在本院门诊和住院就诊的无症状HBe Ag阴性患者32例,采用血清标记物检测,观察瞬时弹性扫描技术联合低拷贝内标定量在无症状慢性HBV感染者的检查效果。结果 HBe Ag阴性患者32例中,HBV-DNA定量(低拷贝内标法)大于1000IU/m L患者PIEALT和PNALT分别为75%和37.5%,HBVDNA定量(低拷贝被标法)500~1000IU/m L患者PIEALT和PNALT分别为16.6%和12.5%,HBV-DNA定量(低拷贝被标法)10~500IU/m L患者PIEALT和PNALT分别为8.3%和25%,P值均小于0.01。瞬时弹性测定肝纤维化与肝硬化,结果显示瞬时弹性测定PIEALT组22例患者≥F2(7.3~9.7KPa)9例(40.9%),≥F3(9.7~17.5k Pa)8例(36.4%),≥F4(>17.5k Pa)5例(22.7%),PNALT组10例患者,≥F2(7.3~9.7KPa)8例(80%),≥F3(9.7~17.5KPa)2例2(20%),≥F4(>17.5k Pa)无。肝功能情况:入组HBe Ag(-)32例患者中,PIEALT组24例,ALT平均(74±26)u/L,AST平均(62±18)u/L,PNALT 8例中,ALT,AST均在正常范围。结论瞬时弹性扫描技术联合低拷贝内标定量可提高无症状慢性HBV感染者检出率,降低严重肝纤维化和肝硬化的发生风险。更多还原

【Abstract】 Objective To explore clinical study of transient elastic scan technique combined with low copy internal standard quantitation in asymptomatic patients with chronic HBV infection. Methods 2015 From March 2015 September, in the hospital outpatient and inpatient visits without symptoms of HBe Ag negative patients(32 cases) were selected. The serum markers detection to observe transient elastography combined with low copy standard quantitative in no symptoms of chronic HBV infection to examine the effect. Results HBe Ag negative patients in 32 cases, HBVDNA quantitative(low copy in the standard method) greater than cells in patients with piealt and pnalt were 75% and 37.5%, HBV-DNA quantitative(low copy is marked by 16.6% and 12.5% respectively for the 500-1000IU/m L patients piealt and pnalt, HBV-DNA quantitative(low copy is standard method) 10-500IU/m L patients piealt and pnalt 8.3% and 25%, respectively, P values were all less than 0.01. Instantaneous elastic determination of hepatic fibrosis and cirrhosis of the liver, the results show that the instantaneous elastic determination piealt group 22 cases of 9 cases of patients with greater than or equal to F2(7.3-9.7k Pa)(40.9%), is more than or equal to F3(9.7-17.5KPa)8 cases(36.4%), ≥F4(> 17.5KPa) in 5 cases(22.7%), pnalt group 10 patients, is more than or equal to F2(7.3-9.7KPa) 8 cases(80%) and more than or equal to F3(9.7-17.5KPa) 2 2(20%), is more than or equal to F4( > 17.5KPa) free. Liver function: into the group HBe Ag(-) 32 cases, PIEALT group of 24 cases, ALT average(74±26)u/L, AST average(62±18)u/L, PNALT 8, ALT, AST are in the normal range. Conclusion Transient elastic scan technique combined with low copy internal standard can improve the detection rate of asymptomatic chronic HBV infection, and reduce the risk of severe liver fibrosis and cirrhosis.更多还原