【摘要】 目的探讨脓毒症相关性血小板减少症的相关危险因素及其对患者预后的影响。方法选取2012年7月~2014年7月于我院接受治疗的80例脓毒症患者作为研究对象,并按照是否伴血小板减少症将其分为A、B两组,A组为血小板减少组,n=30,B组为血小板非减少组,n=50,分析两组患者的一般资料及相关实验室指标、感染控制率及1个月病死率,采取多元回归分析法,总结脓毒症相关性血小板减少症独立危险因素,分析其与患者预后的关系。结果 A组患者血小板减少最低值为(39.1±22.0)×109/L,明显低于B组,其C反应蛋白水平、降钙素原水平分别为(112.4±68.1)mg/L、(7.2±6.1)ng/m L,均高于B组(P<0.05);多元回归分析结果提示:血小板减少<3×109/L、血小板持续减少>1周、脓毒症休克与多器官衰竭为脓毒症相关性血小板减少症的独立危险因素。结论脓毒症患者出现持续性血小板减少、脓毒症休克及多器官衰竭表现是预示患者病情危重的主要指标,提示患者预后水平差,死亡率高。更多还原

【Abstract】 Objective To explore the related factors of disease of sepsis associated thrombocytopenia and the influence on prognosis of patients of sepsis. Methods 80 cases of sepsis patients from July 2012 to July 2014 were treated in our hospital as the research object, according to whether associated with thrombocytopenia were divided into group A, B, group A was reduction group, platelet n=30, group B was reduced platelet group, n=50, analysis of general data and related laboratory index, control rate of infection and mortality rate in1 month of two groups, adopted the multiple regression analysis, summarized sepsis associated thrombocytopenia independent risk factors, analysis of the relationship with prognosis of patients. Results In group A, patients with thrombocytopenia minimum value was(39.1±22)×109/L, was significantly lower than that in group B, the level of C reactive protein, procalcitonin levels in group A were(112.4±68.1) mg/L,(7.2±6.1) ng/m L, were higher than those in group B(P < 0.05); multiple regression analysis indicated: Thrombocytopenia < 3×109/L, platelet sustained reduction of > 1 week, septic shock and multiple organ failure were the independent risk of sepsis associated thrombocytopenia factors. Conclusion Patients with sepsis with persistent thrombocytopenia, septic shock and multiple organ failure performance is the main indicator of critically ill of prognosis of patients, suggests prognosis of patients with poor level, the mortality rate is high.更多还原