【摘要】 目的探讨5-氨基酮戊酸光动力疗法(5-ALA-PDT)治疗面部难治性扁平疣的有效性与安全性研究。方法将符合标准的96例面部难治性扁平疣患者随机分成观察组和对照组各48例,观察组患者使用5-氨基酮戊酸光动力疗法(5-ALA-PDT),对照组患者使用传统CO2激光疗法。比较两组患者疣体数清除率、愈合质量、临床疗效以及复发率和不良反应。结果观察组疣清除率为97.89%,显著高于对照组的81.21%(P<0.05);两组疣体脱1个月后评价愈合质量发现,观察组愈合质量显著高于对照组(P<0.05);此外观察组痊愈率与总有效率分别为87.72%与97.54%,显著性高于对照组的50.34%与79.53%(P<0.05),而不良反应发生率显著低于对照组(P<0.05)。结论 5-ALA-PDT疗法在疣体的愈合质量情况评价、减少疣体复发率及不良反应方面以及提高临床疗效均优于CO2激光疗法。更多还原

【Abstract】 Objective To integrative safety and effectiveness of 5-aminolevulinic acid photodynamic therapy(5-ALA-PDT) in treatment of patients with recalcitrant facial flat warts. Methods 96 patients with this disease were randomly divided into observed group(48 cases) and control group(48 cases). Patients in observed group received the treatment of 5-ALA-PDT, while others received the treatment of CO2 laser therapy. The wart removal rate, quality of healing, clinical effect and recurrence rate and adverse reaction of the two groups were compared. Results The wart removal rate of 97.89% in observation group was significantly higher than that of 81.21% in the control group(P < 0.05); the healing quality of observation group was significantly better than that of the control group(P < 0.05); in addition, cure rate and total effective rate of observation group were 87.72 % and 97.54%, which were significantly higher than those of 50.34% and 79.53% in the control group(P<0.05), while the adverse reaction rate in observation group was significantly lower than that in the control group(P < 0.05). Conclusion Compared with CO2 laser therapy, the treatment of 5-ALA-PDT therapy can improve wart removal rate, quality of healing, clinical effect, reduce recurrence rate and adverse reaction. It is worthy of promotion and application.更多还原