【摘要】 目的:观察咪达唑仑减轻全麻下儿童口腔治疗苏醒期躁动的临床效果。方法:选择儿童口腔科门诊就诊患儿60例,年龄1~7岁,均需在全麻下行口腔治疗,随机均分为3组,每组20例。治疗结束前2min分别静脉给予咪达唑仑0.05mg/kg(A组)、咪达唑仑0.025mg/kg(B组)和生理盐水2mL(C组)。记录麻醉前(T0)、治疗结束时(T1)、拔管时(T2)、拔管后(T3)各时点HR、MAP、SpO2以及拔管时、拔管后5,10,15 min的Ramsay评分和躁动评分。结果:与T0比较,A组T1、T2、T3时点HR、MAP差异无统计学意义(P>0.05),B组和C组T1、T2时点HR比较差异有统计学意义(P<0.05),B组T2,C组T1、T2、T3时点MAP比较差异有统计学意义(P<0.05);与C组比较,A组T2、T3,B组T2时点HR差异有统计学意义(P<0.05),A组各时点MAP比较差异均有统计学意义(P<0.05),A组拔管后10,15 min Ramsay评分比较差异有统计学意义(P<0.01),A组拔管后5,10,15min,B组拔管后15min躁动评分显著降低(P<0.05)。结论:治疗结束前2min静脉给予咪达唑仑0.05mg/kg能有效减轻全麻下儿童口腔治疗苏醒期躁动。更多还原

【Abstract】 Objective:To observe the clinical effects of midazolam by intravenous injection for reducing the occurrence of emergence agitation in children undergoing odontopathy curing after general anesthesia.Methods:Sixty children aged 1to 7years old undergoing odontopathy curing with general anesthesia were allocated randomly into three groups with 20 cases each.Treated with midazolam 0.05mg/kg(A group)and0.025mg/kg(B group)by intravenous injection and the same volume normal saline was given(C group).HR、MAP、SpO2were recorded at the time points of baseline(T0),at the end of the treatment(T1),at extubation(T2)and after extubation(T3),The Ramsay and restlessness score were evaluated at extubation and 5min,10 min and 15 min after extubation.Results:Compared with T0’s,there were no significant differences in the HR and MAP at T1,T2,T3 of A group(P >0.05),there were statistically differences in the HR at T1,T2 of B group and C group,and in the MAP at T2 of B group and T1,T2,T3 of C group(P <0.05);Compared with C group’s,there were statistically differences in the HR at T2,T3 of A group and T2 of B group,and in the MAP at all points of A group(P <0.05),there were statistically differences in the Ramsay at 10,15 min after extubation of A group(P <0.01),the restlessness score at 5,10,15 min after extubation of A group,and at 15 min after extubation of B group significantly decreased(P <0.05).Conclusion:Teating with midazolam 0.05 mg/kg by intravenous injection 2 min before the end of operation could reduce emergence agitation in children undergoing odontopathy curing.更多还原