【摘要】 适应性产热是通过非颤抖性产热维持机体能量代谢平衡的重要方式。研究发现,小鼠体内除棕色脂肪组织外,一些诱因(如寒冷)刺激皮下白色脂肪组织生成的米黄色脂肪也是非颤抖性产热组织。通过调节机体非颤抖性产热过程,促进体内过剩能量以热量形式耗散,可能为肥胖、胰岛素抵抗了等能量代谢紊乱相关病症的治疗提供更安全有效的治疗手段。核受体过氧化物酶体增殖物激活受体γ(PPARγ)是调节脂肪组织功能的重要转录因子,其激动剂在药理学剂量下具有诱导米黄色脂肪细胞生成的作用。本文综述了PPARγ在适应性产热中的调节作用,分析了PPARγ选择性调节作用在非颤抖性产热中的可能机制,以期为新一代胰岛素增敏剂的研发提供理论依据。更多还原

【Abstract】 Adaptive thermogenesis is an important manner to keep homeostasis of energy metabolism by non-shivering thermogenesis(NS). In addition to brown adipose tissue, the beige adipose tissue induced by cold stimulation in subcutaneous white adipose tissue(WAT) also proceeds NS in mice. Regulating NS to increase excess energy expense of the body may be a safe and effective method for the treatment of obesity,insulin resistance and the disorder of energy metabolism. Peroxisome proliferatoractivated receptor γ(PPARγ)is an important transcription factor whose activator can induce the production of adipose tissue cell in pharmacological doses. This paper reviewes the function of PPARγ in adaptive thermogenesis and analyzes the possible mechanism of selective modulation of PPARγ. It may become the theoretical basis of a new generation of insulin sensitizing agent.更多还原