【摘要】 目的探讨血管介入治疗急性脑梗死的临床疗效以及对纤溶性水平的影响。方法选择2012年12月—2013年12月锦州市中心医院收治的急性脑梗死患者100例,随机分为观察组与对照组,各50例,对观察组患者采用血管介入治疗即脑血管球囊成形支架置入术,对对照组患者采用常规治疗方法即低分子肝素钠治疗,对比两组患者的治疗效果,比较观察组、对照组治疗前后的纤溶性水平情况。结果在对两组患者进行分组治疗后,两组患者的临床症状都有所改善,但是观察组患者临床症状改善情况明显优于对照组患者的改善情况,并且在对两组患者的血浆血管性假血友病因子(vWF)、组织型纤溶酶原激活物(tPA)、血浆纤溶酶原激活物抑制剂-1(PAI-1)的水平变化观察后发现,观察组患者的vWF水平和tPA水平明显高于对照组患者,但是观察组患者的PAI-1水平明显低于对照组患者,两组数据有明显差异,具有统计学意义,P<0.05。结论采用血管介入治疗急性脑梗死患者能够有效改善患者的临床症状,并且患者体内的纤溶性水平明显升高,对急性脑梗死的临床治疗有重要意义,值得临床推广。更多还原

【Abstract】 Objective To investigate the effect of vascular intervention in the treatment of acute cerebral infarction and its effect on fibrinolytic level.Methods From December 2012 to December 2013 in 100 cases of acute cerebral infarction patients in our hospital,were randomly divided into observation group and control group,50 cases in each group,the observation group patients with vascular interventional therapy of cerebral vascular balloon angioplasty and stent placement,the control group was treated with routine method for the treatment of low molecular weight heparin sodium in the treatment of,compared two groups of patients with treatment,comparison of the observation group and the control group before and after treatment of fiber soluble level situation.Results In the two groups of patients were divided into two groups,the clinical symptoms of the two groups of patients with improved,but the observation group patients clinical symptom improvement was better than that of the control group of patients to improve the situation and of two groups of patients in blood plasma von Willebrand factor(vWF),tissue type plasminogen activator in mitogen activated plasminogen activator inhibitor 1(PAI- 1) changes in the levels of observation(tPA),plasminogen observation group of patients with vWF level and level of tPA was significantly higher than that of the control group,but observation of PAI-1 levels in patients was significantly lower than that in the control group,patients,two groups of data have obvious difference,with statistical significance(P<0.05).Conclusion The vascular interventional treatment in patients with acute cerebral infarction can effectively improve the patients clinical symptoms and patients in vivo fibrinolysis levels were significantly increased,the clinical treatment of acute cerebral infarction have important significance,it is worth clinical promotion.更多还原