【摘要】 目的探讨精神分裂症患者血清胰岛素样生长因子(insulin-like growth factors,IGFs)水平与精神病理症状的关系。方法研究共纳入精神分裂症患者41例(患者组)和健康受试者40例(对照组),采用阳性与阴性症状量表(PANSS)评估患者精神病性症状,使用酶联免疫吸附法(ELISA)测定血清IGF-1和IGF-2水平。结果患者组血清IGF-1和IGF-2含量均显著低于正常对照组(P<0.05)。相关性分析发现,患者血清IGF-1水平与PANSS阳性症状评分负性相关(r=-0.462,P=0.026),而血清IGF-2水平则与阴性症状评分负性关联(r=-0.395,P=0.034)。结论精神分裂症患者血清IGFs水平存在异常,并与精神病理症状有关,提示IGFs参与精神分裂症的病理过程,可能是疾病症状评估的生物学指标。更多还原

【Abstract】 Objective To investigate the relationships between serum levels of insulin- like growth factors( IGFs) with psychotic symptoms in patients with schizophrenia. Methods Forty- one schizophrenic patients were recruited and 40 healthy volunteers served as controls. The serum contents of IGFs were measured with enzyme linked immunosorbent assay( ELISA) and the psychotic symptoms of patients were evaluated with Positive and Negative Syndrome Scale( PANSS). Results The serum levels of IGF- 1 and IGF- 2 were significantly lower in patients than that in controls( P < 0. 05). Statistical analysis revealed that the serum IGF- 1 level was correlated with the positive symptom subscale( r =- 0. 462,P = 0. 026) while the serum IGF- 2 level was correlated with the negative symptom subscale( r =- 0. 395,P = 0. 034). Conclusion The abnormal levels of serum IGFs are associated with the severity of psychotic symptoms in patients with schizophrenia,indicating that IGFs are involved in the pathogenesis of schizophrenia.更多还原