【摘要】 目的探讨脂蛋白相关磷脂酶A2(LP-PLA2)水平检测对2型糖尿病(T2DM)并发动脉粥样硬化患者的临床意义。方法测定47例T2DM并发动脉粥样硬化患者(患者组),94例健康体检者(对照组)的LP-PLA2、胆固醇(CHO)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平,同时收集上述人群的年龄、性别等相关资料,对两组的检测结果进行比较。结果患者组与对照组在年龄、性别、CHO、TG、HDL、LDL水平方面比较,差异无统计学意义(P>0.05);患者组LP-PLA2水平高于对照组,差异有统计学意义(P<0.05);非条件Logistic多元回归分析显示,LP-PLA2水平是有统计学意义(P<0.05)的危险因素。结论 LP-PLA2水平是T2DM患者并发动脉粥样硬化的危险因素,其检测对T2DM人群动脉粥样硬化病变的发现具有一定价值。更多还原

【Abstract】 Objective To investigate the clinical significance of lipoprotein-associated phospholipase A2(LP-PLA2)measurement for type 2diabetes mellitus(T2DM)patients combined with atherosclerosis.Methods The concentrations of LP-PLA2,cholesterol(CHO),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL)were measured for 47T2 DM patients combined with atherosclerosis(patient group)and 94 healthy people who just underwent healthy examination and were proved to be healthy(control group),meanwhile the age and gender information of those people were collected.Then the tests results were compared between the two groups.Results There was no significant difference in age,gender,CHO,HDL,TG,LDL between the two patient and control group(P>0.05);Plasma LP-PLA2 level in patient group was higher than that in control group,and the difference was statistically significant(P<0.05).Non-conditional Logistic regression analysis showed that the LP-PLA2 level was the risk factor with statistical significance(P<0.05).Conclusion LP-PLA2 concentration is an independent risk factor for atherosclerosis in T2 DM patients,and its measurement has certain value for the diagnosis of atherosclerosis in T2 DM patients.更多还原