【摘要】 目的探讨血清胆碱酯酶(CHE)、α-L-岩藻糖苷酶(AFU)及甲胎蛋白(AFP)联合检测与原发性肝癌(PHC)的相关性。方法选取PHC患者56例(PHC组)、肝硬化(LC)患者52例(LC组)和体检健康者60例(对照组),检测其血清CHE、AFU和AFP水平并行统计学分析。结果 PHC患者血清CHE水平与AFU、AFP均呈负相关(相关系数r分别为-0.889、-0.797,P<0.05),LC患者血清CHE水平与AFU、AFP也呈负相关(相关系数r分别为-0.598、-0.653,P<0.05)。PHC组与LC组3项指标联合检测的阳性率高于对照组,差异有统计学意义(P<0.05)。结论 CHE、AFU及AFP是肝脏病变的敏感指标,联合检测对辅助诊断PHC及监测其病情发展具有重要的临床参考价值。更多还原

【Abstract】 Objective To explore the correlation between the joint detection of cholinesterase(CHE),alpha-L-fucosidase(AFU)and alpha-fetoprotein(AFP)and primary hepatic cancer(PHC).Methods 56 cases of patients with PHC(PHC group),52 cases of patients with liver cirrhosis(LC group)and 60 cases of healthy individuals(control group)were enrolled in this study,and serum levels of CHE,AFU and AFP were detected and statistically analysed.Results Serum levels of CHE in patients with PHC were negatively correlated with levels of AFU and AFP(correlation coefficient was-0.889and-0.797 respectively,P<0.05),the serum levels of CHE in patients with LC were also negatively correlated with levels of AFU and AFP(correlation coefficient was-0.598and-0.653 respectively,P<0.05).The positive rates of joint detection of CHE,AFU and AFP in PHC group and LC group were higher than that in the control group,had statistically significant differences(P<0.05).Conclusion CHE,AFU and AFP are sensitive indicators of liver lesions,and the joint detection could provide reference value for diagnosis and monitoring progression of PHC.更多还原