【摘要】 目的观察消化道恶性肿瘤患者血浆血管性血友病因子(vWF)、抗凝血酶(AT)、D-二聚体(DD)及全血组织因子促凝活性(TF-PCA)检测结果并进行比较。方法使用仪器法对50例消化道恶性肿瘤转移患者(C组)及59例消化道恶性肿瘤未转移患者(B组)的vWF、AT、DD和TF-PCA进行检测,并与60例健康体检者(A组)进行比较。结果与A组比较,B、C两组患者vWF、DD和TF-PCA水平明显增高(P<0.05),AT显著降低(P<0.05);C组较B组vWF、DD和TF-PCA水平增高(P<0.05),AT水平降低(P<0.05);B组及C组内各种疾病之间比较,差异无统计学意义(P>0.05)。结论消化道恶性肿瘤患者存在凝血及纤溶机制失衡,且转移较未转移消化道恶性肿瘤更加明显;其患者血栓前状态只与消化道恶性肿瘤本身有关,与肿瘤发生的消化道部位无明显关系。检测消化道恶性肿瘤患者vWF、AT、DD及TF-PCA水平,可为其病情监测和预后提供参考。更多还原

【Abstract】 Objective To observe the levels of von willebrand factor(vWF),antithrombin(AT),D-dimer(DD)and tissue factor procoagulant activity(TF-PCA)on patients with malignant gastrointestinal tumor and then make comparisons.Methods Use machine to detect the vWF、AT、DD and TF-PCA levels of 50 patients with metastatic gastrointestinal malignant tumor(group C)and another 59 patients with non-metastatic gastrointestinal malignant tumor(group B),and then compare them with those 60 cases of normal physical examination people(group A).Results Compared with group A,the levels of vWF、DD and TF-PCA showed obvious increases(P<0.05)and the level of AT showed a significant decrease(P<0.05)in group B and C.The levels of vWF、DD and TF-PCA in group C were higher than those of group B(P<0.05),but the AT level showed an opposite change(P<0.05).Those comparisons of levels between different diseases in group B and C had no significant difference(P>0.05).Conclusion Patients with malignant gastrointestinal tumor have imbalance in coagulation and fibrinolysis system,and this imbalance is much more obvious in metastatic tumor than non-metastatic tumor.The prethrombotic state indexes of patients are only correlated to gastrointestinal malignant tumor,but not to the parts where the tumor is in.Therefore,the detection of vWF、AT、DD and TF-PCA levels can provide reference for the condition monitoring and prognosis of gastrointestinal malignant tumor.更多还原