【摘要】 目的检测甲状腺功能亢进患者血清亮氨酸氨基肽酶(leucine aminopeptidase,LAP)指标,探讨LAP在甲状腺功能异常患者中的变化及其临床意义。方法选取117例甲状腺功能亢进(简称甲亢)患者作为试验组,109例健康者作为对照组。对比分析不同组间各项实验室指标的差异,并进行LAP和FT3、FT4、TSH的相关性分析。将117例甲亢患者分为肝损害组52例,肝未损害组65例,并进行LAP测定。结果甲亢整体组、甲亢肝损害组、甲亢肝未损害组LAP和FT3、FT4、TSH与正常对照组对比均有统计学差异(P<0.01),血清LAP与FT3、FT4成正相关,与TSH成负相关;甲亢肝损害组LAP和FT3、FT4、TSH与甲亢肝未损伤组对比无统计学差异(P>0.05)。结论血清LAP含量与甲状腺激素关系密切,对甲状腺功能亢进患者诊断、病情评估、以及治疗用药有一定的临床参考价值。LAP可以作为甲亢的一个独立诊断指标。更多还原

【Abstract】 Objective To detect serum leucine aminopeptidase(LAP)level in the patients with hyperthyroidism for investigating the changes of LAP in the patients with thyroid dysfunction and its clinical significance.Methods 117 patients with hyperthyroidism were taken as the test group and 109 healthy people as the control group.The differences of various laboratory indexes were comparatively analyzed and the correlation between LAP with FT3,FT4 and TSH was analyzed.117 patients with hyperthyroidism were divided into the liver damage group(52cases)and non-liver damage group(65cases)and performed the LAP determination.Results The serum LAP,FT3,FT4 and TSH levels in the hyperthyroidism whole group,hyperthyroidism liver damage group and hyperthyroidism non-liver damage group had statistically significant differences compared with those in the control group(P<0.01),serum LAP was positively correlated with FT3 and FT4,and negatively correlated with TSH;LAP,FT3,FT4 and TSH had no statistical differences between the hyperthyroidism live damage group and the hyperthyroidism non-liver damage group(P>0.05).Conclusion The serum LAP content is closely related with the thyroid hormones and has certain clinical reference value for the diagnosis,disease condition evaluation and medication.Lap can serve as an independent diagnostic indicator.更多还原