【摘要】 目的:分析小剂量人绒毛膜促性腺激素(h CG)联合人绝经期促性腺激素(h MG)对低促性腺激素性性腺功能减退症(hypogonadotropic hypogonadism,HH)患者促排卵的作用。方法:11例HH者(研究组)于月经第5天开始应用小剂量h CG(100~200 IU/d)联合h MG(150 IU/d)促排卵23个周期。5例HH者(对照组)于月经第5天开始仅应用h MG(150 IU/d)促排卵9周期。对2组HH患者周期应用h MG总剂量、连续刺激时间、诱发排卵日获得平均直径≥18 mm卵泡数、子宫内膜厚度、周期妊娠率进行比较。结果:12组年龄、体质量指数(BMI)、诱发排卵日获得平均直径≥18 mm卵泡数、子宫内膜厚度和周期妊娠率比较差异均无统计学意义(均P>0.05)。2研究组和对照组促排卵周期应用h MG总剂量分别为(1 829.35±625.35)IU和(2 408.33±263.69)IU,差异有统计学意义(P<0.05)。3研究组和对照组促排卵连续刺激时间分别为(15.04±2.94)d和(22.89±1.96)d,差异有统计学意义(P<0.001)。结论:小剂量h CG联合h MG对HH患者促排卵,在维持高周期妊娠率的前提下,可减少h MG用量和缩短促排卵连续刺激时间。更多还原

【Abstract】 Objective: To explore the application of the low-dose human chorionic gonadotropin(h CG)combined with human menopausal gonadotropin(h MG) in ovulation induction for those patients with hypogonadotropic hypogonadism(HH). Methods: 11 cases of HH(23 cycles total) received the low-dose h CG(100~200 IU/d) combined with h MG(150 IU/d) for ovulation induction from the fifth day of cycle, as the study group. 5 cases of HH(9 cycles total), as the control group, received only h MG(150 IU/d) for ovulation induction.Total dose of h MG,ovulation stimulate days,the number of oocyte with mean diameter ≥18 mm, the endometrium thickness on the day of induced ovulation and the pregnancy rate of induction cycle were compared.Results: 1 There were not significant differences in age,BMI,the number of oocyte with mean diameter ≥18mm, the endometrium thickness on the day of induced ovulation and the pregnancy rate of induction cycle between 2 groups(P>0.05). 2Total dose of h MG in induction cycle in the study group was significantly lower than that in the control group[(1 829.35±625.35)IU vs.(2 408.33±263.69 IU),P<0.05]. 3The continued days of ovulation induction in the study group were significantly less than those in the control group[(15.04±2.94)d vs.(22.89 ±1.96)d,P <0.001]. Conclusions: The low-dose h CG combined with h MG in ovulation induction for patients with HH can decrease the dose of h MG and shorten the days of ovulation induction stimulate, with the high pregnancy rate of induction cycle.更多还原