【摘要】 目的观察慢性阻塞性肺疾病(COPD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)(简称重叠综合征,OS)患者维生素D水平,并探讨维生素D缺乏对OS患者的影响。方法收集健康对照者和OS患者各36例,采集临床资料并进行多导睡眠图(PSG)监测。用酶联免疫吸附法(ELISA)测定血清中的25-羟维生素D[25-(OH)D]水平;将OS患者的体质量指数(BMI)、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSa O2)、FEV1%和25-(OH)D水平作相关分析。结果 OS患者的血清中25-(OH)D水平明显低于健康对照者(P<0.05)。OS患者的25-(OH)D水平与患者BMI、AHI呈负相关(P<0.05);与患者FEV1%和LSa O2呈正相关(P<0.05)。结论维生素D缺乏在OS患者中患病率高,且维生素缺乏与OS患者的BMI、AHI、LSa O2和FEV1%相关。更多还原

【Abstract】 Objective To observe the vitamin D levels in the patients with chronic obstructive pulmonary disease(COPD)and obstructive sleep apnea hypopnea syndrome(OSAHS)(overlap syndrome, OS), and to explore the effect of vitamin D deficiency on the OS patients. Methods Thirty-six healthy subjects and thirty-six OS patients were enrolled in our study. The clinical and polysomnography data of healthy subjects and OS patients were collected, the serum levels of 25-(OH) D were measured by ELISA. The body mass index(BMI), the apnea hypopnea index(AHI), the lowest oxygen saturation(LSaO2)、the FEV1% and the levels of 25-(OH) D in OS patients were used for correlation analysis. Results The levels of 25-(OH)D were significantly lower in the OS patients than that in the healthy controls(P< 0.05). 25-(OH)D levels were negatively correlated with BMI and AHI(P< 0.05), and positively correlated with LSaO2 and FEV1%(P< 0.05). Conclusion Vitamin D deficiency is highly prevalent in OS patients, which correlated with BMI, AHI, FEV1% and LSaO2 in OS patients.更多还原