【摘要】 目的比较序贯法和点斜法测定右美托咪定治疗麻醉后寒战的半数有效量(ED50)的异同。方法选取2013年1月至6月于我院进行择期手术美国麻醉师协会(ASA)1-2级患者60例,随机分为序贯法组和点斜法组,各30例,分别以序贯法及点斜法测定ED50。观察记录平均动脉压(MBP)、心率(HR)、呼吸频率(RR)、脉搏血氧饱和度(SpO2)、肛温及寒战发生率。结果与给药前相比,两组患者给药15、30、60 min后HR、MBP、RR和SpO2无显著改变。两组HR、MBP、RR和SpO2各时间点比较差异也无统计学意义。两组患者围术期不同时间点体温与同组麻醉前相比均降低(P<0.05)。两组麻醉后寒战分级及发生率差异无统计学意义。结论序贯法和点斜法测定右美托咪定麻醉后寒战ED50均为0.4μg/kg,两种方法均可以用于麻醉后寒战ED50的测定。更多还原

【Abstract】 Objective To compare the comformity of sequential method and point-slope method on chills ED50 determination after dexmedetomidine narcotic. Methods A total of 60 cases of elective surgery patients were randomly divided into two groups: sequential method group and point-slope method group, 30 cases in each. The recorded mean arterial pressure(MBP), heart rate(HR), respiratory rate(RR), pulse oximetry(SpO2), incidence of rectal temperature and chills were observed. Results HR, MBP, SpO2 and RR in two groups were administered before and after administration of 15, 30 and 60 min. There was no signifi cant difference. Patients of two groups at each time point HR, MBP, SpO2 and RR of were not signifi cantly different. Perioperative temperacture of at different time points, all patients decreased compared with before anesthesia(P<0.05). There were no signifi cant differences in post-anesthesia shivering classifi cation and incidence. Conclusion After dexmedetomidine anesthesia, both sequential method and point-slope method can be used to determine shivering ED50.更多还原