【摘要】 目的:观察艾滋病患者不同CD4~+T淋巴细胞计数与机会感染的关系。方法:2010年1月--2014年1月确诊的艾滋病患者80例,其中CD4~+T淋巴细胞计数>200个/μl者40例为观察组,CD4~+T淋巴细胞计数≤200个/μl者40例为对照组,对所有患者随访2年,比较两组患者随访期间发生机会感染情况及机会感染累及部位和持续时间。结果:观察组患者皮肤白色念珠菌感染、间质性浆细胞肺炎、隐孢子虫感染性腹泻及结核杆菌感染等机会感染的发生率显著低于对照组(P均<0.05),观察组累及部位显著少于对照组(P<0.05),发生机会感染持续时间显著短于对照组(P<0.05)。结论:CD4~+T淋巴细胞计数水平是机体机会感染的有效预测指标,随着CD4~+T细胞数量减少,机会感染的发病率增高,累及部位增加,持续时间延长。更多还原

【Abstract】 Objective: To study the relationship between CD4~+T lymphocyte count and opportunistic infection in acquired immune deficiency syndrome(AIDS) patients. Methods: Eighty patients were diagnosed as AIDS from January 2010 to January 2014, and they were divided into observation group(CD4~+T lymphocyte>200/μl) and control group(CD4~+T lymphocyte count ≤ 200/μl) according to the CD4~+T lymphocyte count. After two years of follow-up, the incidence, the location and duration of opportunistic infections were compared between the two groups. Results: Compared to the control group, the incidence of skin Candida albicans infection(27.5% vs.62.5%), Pneumocystis carinii pneumonia(30.0% vs.65.0%), Cryptosporidium diarrhea( 35.0% vs.70.0%) or infection of Mycobacterium tuberculosis( 27.5% vs.70.0%) was significantly lower in the observation group(P<0.05), the infection sites were less in number(2.1±0.2 vs. 3.5±0.4,P<0.05), and the duration of the opportunistic infection was shorter [(2.5±1.1) months vs.(5.6±1.4) months,P<0.05]. Conclusion: CD4~+T lymphocyte count is reliable predictor of opportunistic infections. The incidence of opportunistic infections is higher, the infection sites are more in number, and the duration of infection is longer in patients with low levels of CD4~+T lymphocyte.更多还原