Based on a recently proposed indirect approach,a 2,2'-dipicolyamine( D PA) appended porphyrin( TPP-D PA)was designed and synthesized as aTurn Onfluorescent probe for α-amino acids in DMSO. The strong fluorescence of TPP-DPA could be quenched by trace amount of copper ions and the resulting TPP-D PA + Cu~(2+)complex can serve as aTurn Onfluorescent chemosensor for α-amino acids,especially for HS-containing α-amino acids,such as cysteine. According to the reported indirect design method and results we have ob...