【摘要】 目的探讨多西他赛联合顺铂及氟尿嘧啶辅助化疗方案（DCF）对有淋巴结转移的食管癌患者进行三野根治术术后长期预后的影响。方法将109例局部进展期食管癌患者按术后是否用DCF辅助化疗方案分为对照组58例和试验组51例。对照组术后未给予任何化疗方案;试验组术后给予DCF辅助化疗方案(500 mg·m^-2氟尿嘧啶,第1⁴天+60 mg·m^-2多西他赛,第1天+60mg·m^-2顺铂,第1天),治疗2个周期。根据患者淋巴结转移的程度,将患者细分为N1亚组（68例）及N2亚组（41例）。比较2组患者的总体生存率、无瘤生存率以及不良反应发生率。结果治疗后对照组与试验组的总体生存率分别为51.23%和54.08%（P>0.05）,无瘤生存率分别为45.54%和48.58%（P>0.05）。N1亚组:对照组与试验组的总体生存率及无瘤生存率比较差异均无统计学意义（P>0.05）。N2亚组:对照组与试验组的总体生存率分别为28.58%和42.10%（P<0.05）;无瘤生存率方面分别为25.03%和38.65%（P<0.05）。试验组的不良反应发生率为17.65%（9/51）。结论 DCF辅助化疗可提高进行三野根治术、有3⁶枚淋巴结转移的食管癌患者的术后长期生存率及无瘤生存率且不良反应较小。更多还原

【Abstract】 Objective To explore the effects of postoperative adjuvant chemotherapy with docetaxel + cisplatin + 5- fluorouracil（DCF） on the long term prognosis in esophageal cancer patients with lymph node metastasis.Methods One hundred and nine patients with squamous cell carcinoma were divided into control group（n = 58） and treatment group（n=51）.Control group was given surgery alone.Treatment group was received postoperative DCF therapy,500 mg·m^-2 5- fluorouracil on days 1- 4,60 mg·m^-2 docetaxel on day 1 and 60 mg·m^-2 cisplatin on day 1.The efficacy of DCF treatment was investigated in patients divided according to the number of metastatic lymph nodes,which was divided into N1 cases（n =68） and N2 cases（n =41）.The disease-free,overall survival and adverse drug reactions were compared between the groups.Results The disease- free and overall survival were45.54%and 51.23%,respectively,in the control group and 48.58%and 54.08%,respectively,in the treatment group.These differences were not considered to be statistically significant（P > 0.05）.Although there were no significant differences in disease- free and overall survival between the treatment and control group in N1 cases,both disease-free and overall survival were found to be better in the treatment group（38.65%and 42.10%,respectively） compared to those in the control group（25.03%and 28.58%,respectively） in N2 cases（P <0.05）.The incidence of adverse drug reactions in the treatment group was 17.65%（9/51）.Conclusion Therefore,postoperative adjuvant chemotherapy with DCF was shown to improve disease- free and overall survival in moderate lymph node metastasis- positive cases（N2）,suggesting that the DCF regimen may be effective as postoperative adjuvant chemotherapy for patients with lymph node metastasis from esophageal cancer.更多还原