【摘要】 目的评价雷公藤多苷与小剂量糖皮质激素治疗免疫球蛋白A肾病的临床疗效及其对患者T淋巴细胞亚群的影响。方法入选免疫球蛋白A肾病患者86例(试验组)和健康者91例(对照组)作为研究对象。试验组口服氯沙坦钾50 mg·d-1,qd+醋酸泼尼松片0.5 mg·kg-1,qd+雷公藤多苷片1 mg·kg-1,tid,疗程为3个月。分别检测患者治疗前后及健康查体人员血清T淋巴细胞Th1/Th2细胞因子及免疫球蛋白A的临床疗效。结果治疗前,试验组干扰素(IFN)-γ和白细胞介素(IL)-2显著低于对照组(P<0.05);IL-4和IL-10显著高于对照组(P<0.05)。治疗3个月后,试验组临床总有效率为91.8%。治疗后,试验组患者尿素氮、尿酸和血肌酸酐均较治疗前显著降低(P<0.05);IFN-γ及IL-2较治疗前显著升高(P<0.05),IL-4及IL-10较治疗前显著降低(P<0.05)。结论雷公藤多苷治疗免疫球蛋白A肾病的临床疗效确切,对患者T淋巴细胞亚群失衡有一定的调节作用。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of tripterygium glycosides and small dose of glucocorticoid on Ig A nephropathy and its influence on T lymph cells. Methods A total of 86 patients with Ig A nephropathy were enrolled as the treatment group and 91 cases of healthy controls were recruited as the control group. Patients in the treatment group were administered with cozaar 50 mg·kg- 1,qd orally plus prednisone 0. 5 mg · kg- 1,qd orally plus tripterygium glycosides 1 mg·kg- 1tid orally for 3 months. The data of clinical efficacy in treatment group and Th1 / Th2 before and after treatment in two groups were recorded and compared. Results The serum level of interferon( IFN)- γ and interleukin( IL)- 2 in treatment group were significantly lower than those in control group( P < 0. 05). And the serum level of IL- 4 and IL- 10 were significantly higher than those in control group( P < 0. 05). After 3months treatment,the total effective rate was 91. 8% in treatment group.The serum level of urea nitrogen,uric acid,and creatinine were significantly decreased after treatment( P < 0. 05). After treatment,the serum level of IFN- γand IL- 2 was significantly elevated( P < 0. 05),and the level of IL- 4 and IL- 10 was significantly decreased( P < 0. 05).Conclusion Tripterygium glycosides is effective in treatment of Ig A nephropathy,which could also improve the T lymph cell immune system.更多还原