【摘要】 目的观察利培酮对精神分裂症患者血脂和甲状腺激素的影响。方法入选2011年5月至2011年10月上海精神卫生中心收治的精神分裂症患者41例为研究对象,单用利培酮治疗,疗程8周。分别于治疗前、治疗8周末测定总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C);检测血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)。比较分析自身治疗前后的差异。结果利培酮治疗后,三酰甘油明显升高,与治疗前比较差异有统计学意义(P<0.01);T3、FT3、FT4显著下降,差异有统计学意义(P<0.01)。结论临床上用利培酮治疗精神分裂症患者时,可致血脂异常和甲状腺激素水平下降,应加强血脂及甲状腺激素水平监测,保证其治疗的安全性。更多还原

【Abstract】 Objective To observe the effects of risperidone on lipids and thyroid hormone in patients with schizophrenia. Methods Forty-one cases of schizophrenia patients were enrolled from May to October in2011,respectively and were treated with risperidone alone for 8 weeks.The data of the total cholesterol( TC),triglyceride( TG),low density cholesterol( LDL- C),and high density cholesterol( HDL- C) were measured before and after treatment. The data of three serum triiodothyronine( T3),thyroxine three( T4),free triiodothyronine( FT3),free thyroxine( FT4) and thyroid stimulating hormone( TSH) were detected.The changes were recorded and compared. Results After risperidone therapy, TG increased significantly compared with before treatment( P < 0. 01). The data of T3,FT3 and FT4 decreased significantly( P < 0. 01). Conclusion Risperidone may cause abnormal drop of blood lipid and thyroid hormone level,therefore,related monitors should be strengthened to ensure the safety during treatment of schizophrenia patients.更多还原