【摘要】 目的探讨非酒精性脂肪性肝病(NAFLD)患者血清β抑制蛋白(ARRB)表达情况及临床意义。方法将83例NAFLD患者分为非酒精性脂肪肝的无纤维化组与纤维化组(分别简称为无纤维化组与纤维化组),分别进行血清ARRB1、ARRB 2、胰岛素及空腹血糖检测,并与20例健康者进行比较。结果纤维化组患者的血清ARRB1、ARRB2及胰岛素水平显著高于无纤维化组及健康组(P<0.05),但3组血清空腹血糖水平差别无统计学意义(P>0.05)。结论ARRB可能参与了NAFLD的肝纤维化进展。更多还原

【Abstract】 Objective To evaluate the clinical significance of the determination on the β- arrestin serum( AEEB) expression in patients with non nalcoholic fatty liver disease( NAFLD).Methods Total of the 83 cases with NAFLD divided into two groups: nonalcoholic fatty liver with fibrosis group( A group) and nonalcoholic fatty liver without fibrosis group( B group).Twenty health subjects was as healthy control group( C group).All of the included subjects were tested for serum β- arrestin1,β- arrestin 2,insulin( INS) and fasting plasma glucose.Results The serum β- arrestin 1,β- arrestin 2,INS in group A were much higher than that in group B and group C with statistical difference( P < 0.05).But the fasting plasma glucose level in serum was not statistical difference( P >0.05).Conclusion β- arrestin may participate in the development of nalcoholic fatty liver disease.更多还原