【摘要】 目的:探讨七叶皂苷钠、纳洛酮联合应用治疗重型颅脑损伤的临床疗效。方法:在传统治疗基础上分别以七叶皂苷钠+纳洛酮、七叶皂苷钠和纳洛酮设为治疗组、对照1组、对照2组对重型颅脑损伤患者进行治疗。比较3组颅内压、GCS评分和头颅CT脑水肿变化,进行疗效评价及预后评估。结果:3组患者用药后颅内压(ICP)值比较,治疗组明显低于2个对照组,且下降趋势明显(P<0.05),而对照1组与对照两组比较无统计学意义(P>0.05);GCS评分比较治疗组明显高于2个对照组,呈明显上升趋势(P<0.05),而对照1组与对照2组比较无统计学意义(P>0.05);CT脑水肿治疗组较2个对照组明显缩小(P<0.05),而对照1组与对照2组比较无统计学意义(P>0.05)。结论:七叶皂苷钠、纳洛酮联合应用能明显降低重型颅脑损伤患者颅内压、提高GCS评分和缩小脑水肿范围。更多还原

【Abstract】 Objective:To investigate the clinical effect of sodium aescinate combined with naloxone in the treatment of severe craniocerebral injury.Methods:On the basis of the conventional treatment,patients with severe craniocerebral injury were respectively treated with sodium aescinate combined with naloxone(treatment group),sodium aescinate(control group 1)and naloxone(control group2).The intracranial pressure,GCS and brain edema changes scanned by skull CT of the 3groups were compared,and the results of the therapeutic evaluation and prognosis evaluation were statistically analyzed.Results:After taking medicine,ICP of the treatment group was obviously lower than that of the 2control groups,and declined significantly(P<0.05),but there was no obvious difference between the 2control groups(P>0.05).GCS of the treatment group was higher than that of the 2control groups,and increased obviously(P<0.05),but there was no significant difference between the 2control groups(P>0.05).Brain edema of the treatment group reduced more obviously than that of the 2control groups(P<0.05),but there was no obvious difference between the 2control group(P>0.05).Conclusion:Sodium aescinate combined with naloxone can obviously reduce the intracranial pressure,increase the GCS and shrink the brain edema of patients with severe craniocerebral injury.更多还原