【摘要】 合成了2个新的化合物——邻香草醛缩组氨酸Schiff碱及其镧配合物.通过元素分析、X射线衍射、红外光谱、紫外-可见光谱、热重-差热分析及化学分析等对它们进行了表征.结果表明,邻香草醛缩组氨酸Schiff碱为2-[(2-羟基-3-甲氧基-苯亚甲基)-氨基]-3-(2-咪唑基)-丙酸一水合物(C14H15N3O4·H2O),Schiff碱镧配合物为二氯-{2-[(2-羟基-3-甲氧基-苯亚甲基)-氨基]-3-(2-咪唑基)-丙酸}合镧(Ⅲ)三水合物[La(C14H15N3O4)Cl2·3H2O].应用生物微量热法研究了这2个化合物的生物活性,在301.15 K下测定了2个化合物存在时粟酒裂殖酵母细胞代谢的产热曲线,计算得到了粟酒裂殖酵母细胞生长速率常数(k)、传代时间(tG)、总热效应(Qtotal)、抑制率(I)及半抑制浓度(IC50)等热动力学参数.结果表明,随着C14H15N3O4·H2O和La(C14H15N3O4)Cl2·3H2O浓度的增加,k和Qtotal减小,tG和I增加,IC50分别为0.2585和0.2488mmol/L.更多还原

【Abstract】 Two new compounds,o-vanillin-histidine Schiff-base and its lanthanum(Ⅲ) complex,were synthesized.Element analysis,X-ray diffraction analysis,ultraviolet-visual spectra,infrared spectra,thermogravimetry-differential thermal analysis and chemical analysis were employed to characterize the compositions and structures of o-vanillin-histidine Schiff base and its lanthanum(Ⅲ) complex.The results show that the molecular formula of the o-vanillin-histidine Schiff base and lanthanum(Ⅲ) Schiff base complex are C14H15N3O4·H2O and La(C14H15N3O4) Cl2·3H2O,respectively.The biological activities of C14H15N3O4·H2O and La(C14H15N3O4) Cl2·3H2O were studied using biological microcalorimetry.The metabolic thermogenic curves of S.pombe were measured at 301.15 K.Some thermokinetic parameters of growth and metabolism of S.pombe,such as the rate constant(k),generational time(tG),total thermal effects(Qtotal),inhibition ratio(I) and half inhibition concentration(IC50),etc.,were calculated.Experimental results show that the k and Qtotalvalues of S.pombe decrease,while tGand I values of S.pombe increase with the increase of the concentrations of C14H15N3O4·H2O and La(C14H15N3O4) Cl2·3H2O.The IC50 values for C14H15N3O4·H2O and La(C14H15N3O4) Cl2·3H2O were found to be 0.2585 and 0.2488 mmol / L,respectively.更多还原