【摘要】 目的探讨血清淀粉样蛋白A在重症监测病房(ICU)早期感染中的诊断价值。方法收集本院2013年6月至2013年12月之间入住ICU超过2 d的患者,所有患者均检测血清淀粉样蛋白A(SAA)和高敏C反应蛋白(hs CRP)。根据痰培养(深部无菌吸痰)结果将所有患者区分为正常组与感染组。分别比较正常组与感染组之间的血清淀粉样蛋白A和高敏C反应蛋白变化。结果研究对象入选381例,其中细菌感染组106例,正常对照组275例。SAA在正常对照组与细菌感染组结果分别为5.00 mg/L(95%CI:5.00~5.00 mg/L)与105.12 mg/L(95%CI:48.89~212.47 mg/L);hs CRP在正常对照组及细菌感染组中分别为9.13 mg/L(95%CI:3.87~14.47 mg/L)和28.15 mg/L(95%CI:16.81~39.63 mg/L)。SAA与hs CRP在正常组与感染组之间呈显著性差异(P<0.001)。结论 SAA及hs CRP联合检测在ICU早期细菌感染中敏感性较高,具有辅助诊断价值。更多还原

【Abstract】 Objective To assess the diagnostic value of serum amyloid A(SAA) for early infection in the intensive care unit(ICU).Methods Patients who stayed in ICU for more than 2 days were enrolled from June,2013 to December,2013.SAA and high-sensitivity C-reactive protein(hs CRP) were examined in all patients.Patients were divided into two groups(normal group and infected group) based on the result of sputum culture(deep sterile suction).The results of SAA and hs CRP were compared between the two groups.Results 381 patients were enrolled,including 106 patients with bacterial infection and 275 patients without infection.The mean levels of SAA were 5.00 mg / L(95%CI 5.00-5.00 mg / L) and 105.12 mg / L(95%CI 48.89-212.47 mg / L) in the normal group and the infection group respectively; The mean levels of hs CRP were 9.13 mg / L(95%CI3.87-14.47 mg / L) and 28.15 mg / L(95%CI 16.81-39.63 mg / L) in the normal group and the infection group respectively.There are significant differences between the normal group and the infected group in SAA and hs CRP(P <0.001).Conclusion The combined detection of SAA and hs CRP is sensitive to early bacterial infection in ICU.They are valuable to the diagnosis of early bacterial infection.更多还原