【摘要】 介孔纳米二氧化硅是一种优良的药物运输载体,合成介孔纳米二氧化硅通常需要加入十六烷基三甲基溴化铵做结构导向剂,但CTAB有很强的细胞毒性,因此将介孔纳米二氧化硅作为药物载体用于体内或体外实验时,一定要选择合适的方法将CTAB去除干净。文章合成了一种介孔纳米二氧化硅,采用酸性乙醇萃取法与高压蒸气法结合将CTAB完全除去,此种方法目前未见文献报道。更多还原

【Abstract】 Mesoporous nano silica was an excellent drug delivery carrier, and usually it was synthesized by using cetyltrimethylammonium bromide as the structure-directing agent, but CTAB possessed high cytotoxicity, so CTAB must be removed entirely with efficient method before it is used in cell or animal experiment. Mesoporous nano silica was synthesized in this paper, and CTAB was entirely removed by the combination of acidic ethanol extraction and high pressure steam, which was not reported in the other papers.更多还原