【摘要】 以3-羟基-4-苯基-5-苯甲酰基-N-甲基-2-吡咯烷酮(1)为原料,用N,N-二甲氨基甲酰氯将其3位羟基酯化,得3-(N,N-二甲氨基)甲酰氧基-4-苯基-5-苯甲酰基-N-甲基-2-吡咯烷酮(2),反应总收率为4.6%。以抑制乙酰胆碱酯酶作为生物活性评价指标,实验结果显示,其对乙酰胆碱酯酶无抑制作用。更多还原

【Abstract】 3-(N,N-Dimethylamino)formyloxy--4-phenyl-5-benzoyl-N-methyl-2-pyrrolidone was preparation from3-hydroxy-4-phenyl-5-benzoyl-N-methyl-2-pyrrolidone with the yield of 4.6 %.The experiment indicate that Title compound 2 has no obvious effect on acetylcholinesterase inhibitory activity,Further structural modification and activityevaluation are in progress.更多还原