【摘要】 复方口服避孕药(combined oral contraceptives,COCs)由外源性雌孕激素配伍而成,主要是通过高于生理水平的雌孕激素负反馈抑制垂体-卵巢轴,降低内源性促性腺激素和性激素的水平,影响卵泡的发育而避孕。但在周期性的COCs的无活性药间期(hormone-free interval,HFI)会有垂体-卵巢轴活性的恢复,其激素水平的变化及卵泡发育的情况与雌激素的剂量、孕激素的剂型、HFI的改变相关。更多还原

【Abstract】 The combined oral contraceptives(COCs)are combinations of exogenous estrogen and progestin. The primary mode of action for COCs is thought to be suppression of the pituitary- ovarian axis by higher than physiological levels of estrogen and progestin,secondarily leading to suppression of endogenous gonadotropin and gonadal hormone secretion and ovarian function. During the hormone-free interval(HFI),COCs users experience activation of their pituitary- ovarian axis. The level of hormones and follicular development are associated with the doses of estrogen,progestin formulations and the changes of HFI.更多还原