【摘要】 痂囊腔菌素A在光疗窗口(600~900 nm)的弱吸收,限制了它在临床上的使用。为解决这一问题,并对该化合物的进一步修饰提供基础,合成得到了γ-氨基丁酸修饰的痂囊腔菌素A衍生物,利用核磁共振、质谱等方法确定了衍生物结构。吸收光谱和电子顺磁自旋光谱表明,该衍生物不仅在光疗窗口具有良好的吸光能力,而且具有良好的活性氧物种产生能力。更多还原

【Abstract】 To overcome the lack of appreciable absorption in the phototherapeutic window( 600 ~ 900 nm) of the naturally occurring perylenequinonoid pigment,Elsinochrome A,which limited its clinical application,an γ-amino butyric acid-modified elsinochrome A,possessing long wavelength absorption( 640 nm) was synthesized. Electron paramagnetic resonance indicated that γ-amino butyric acid-modified elsinochrome A possessed photosensitizing activity and its yield of reactive oxygen species( ROS) was greater than that of unmodified Elsinochrome A.更多还原