A HPCE method was developed for the chiral separation and analysis of metoprolol enantiomers. Theβ1-blockers metoprolol succinate and metoprolol tartrate were separated successfully by the capillary zone electrophoresis( CZE) with PDA detection at 220 nm and β-CD as chiral reagent. Effects of the main factors affecting the HPCE chiral separation,including composition of the running buffer,p H value,concentration of the buffer,separation voltage,and type of the chiral reagent etc,were investigated. The basel...
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