【摘要】 采用不同剂量(12、20、40、80 Gy)X射线照射昆明种小白鼠,于照前或照后给予富勒烯多大环多胺衍生物(CB),研究富勒烯衍生物对X射线所致小鼠急性肝线粒体损伤的保护作用。结果表明,不同剂量X射线照射可使小鼠肝线粒体氧化受损,表现为线粒体肿胀,发生脂质过氧化反应,产生脂质过氧化物——丙二醛等物质,用富勒烯大环多胺衍生物干预的小鼠可明显减少线粒体肿胀及脂质过氧化物的形成。说明富勒烯大环多胺衍生物有助于减轻辐射引起的线粒体受损,维护线粒体结构和功能的完整性。更多还原

【Abstract】 To investigate whether fullerenes derivatives have protective effect to acute liver injury,we irradiated the Kunming mice with different doses of X-rays( 12,20,40,80 Gy),and injected fullerene derivative( CB) before or after irradiation. Experimental results show that the radiation can strongly induce free radical and damage to mitochondria,such as: to swell mitochondria,to produce lipid peroxidation and malondialdehyde( MDA). Chelating agent can significantly reduce the swelling of mitochondria and the formation of MDA,so as to maintain the structure integrity and function of mitochondria.更多还原