【摘要】 目的探讨不同程度脓毒性休克患儿血清高密度脂蛋白胆固醇(HDL-C)、胱抑素C(Cys-C)变化特点及对预后的影响。方法检测脓毒性休克重度组25例、脓毒性休克轻度组23例患儿入院时的HDL-C及Cys-C,并与健康体检儿童(正常对照组)25例进行对比分析。脓毒性休克重度组、轻度组于入院后1、3、6、9d动态监测以上指标;密切观察病情变化,记录死亡情况和住院天数。结果脓毒性休克重度组、轻度组入院时的HDL-C明显降低,Cys-C明显升高,这两个指标3组相比,差异均有统计学意义(F值分别为294.105、344.863,P值均小于0.01)。脓毒性休克重度组与轻度组比较,病死率明显较高(χ2=0.023,P<0.05),存活者住院天数及HDL-C、Cys-C恢复正常水平时间明显延长(t值分别为11.433、9.731、3.501,P值均小于0.01)。结论 HDL-C、Cys-C在一定程度上体现脓毒性休克患儿病情的危重程度,血清HDL-C越低、Cys-C越高,其病情程度越重,恢复正常水平时间越长,预后越差。更多还原

【Abstract】 Objective To investigate the clinical signification of detection of high density lipoprotein cholesterol(HDLC)and cystatin C(Cys-C)in child patients with septic shock.Methods Serum HDL-C and Cys-C were analyzed in 25 cases with severe septic shock and 23 cases with mild septic shock at day 1,3,6,9,and compared with those of 25 volunteers.Result Serum HDL-C in septic shock decreased significantly,Serum Cys-C levels in septic shock was higher than the normal person on day 1,there were significant differences in three groups(F value was 294.105 and 344.863respectively;P values were all below 0.01).The mortality was significantly higher in severe septic shock as compared with that of mild septic shock(χ2=0.023,P<0.05),HDL-C and Cys-C levels recovered more slowly in severe septic shock than those in mild septic shock(t value was 11.433,9.731,and 3.501respectively;P values were all below 0.01).Conclusion The detection of the serum HDL-C and Cys-C can be useful biochemistry parameters for the diagnosis and treatment of septic shock.更多还原