【摘要】 目的比较伴有高泌乳素血症的多囊卵巢综合征(PCOS)患者和单纯PCOS患者胰岛β细胞功能及胰岛素抵抗(IR)的差异。方法 2004年6月至2011年6月我院妇科门诊PCOS患者350例,其中伴有高泌乳素血症41例(A组),单纯PCOS患者309例(B组),比较两组之间的一般情况、血清性激素及糖代谢和胰岛β细胞功能的指标。结果除泌乳素外,A组患者的痤疮发生率、血清睾酮较B组明显增高[分别为48.3%vs 28.1%,P<0.05;(1.5±0.6)ng/mL vs(0.8±0.2)ng/mL,P<0.05];A组的HOMA-IR较B组明显升高(3.2±1.6 vs 1.9±1.5,P<0.05)。结论伴有高泌乳素血症的PCOS患者较单纯PCOS患者的内分泌紊乱程度更高,IR更明显,可能更易发生胰岛β细胞功能失调。更多还原

【Abstract】 Objective To compare the beta-cell function and insulin resistance(IR)between polycystic ovary syndrome(PCOS)patients with hyperprolactinemia(HPRL)and PCOS patients without HPRL.Methods A total of 350 PCOS patients were collected and divided into two groups,including 41 PCOS patients with HPRL(group A)and 309 PCOS patients without HPRL(group B).The clinical situation,sex hormone,and glucose metabolic parameters were compared between the two groups.Results An higher incidence of acne(48.3%vs 28.1%,P<0.05),a higher level of testosterone[(1.5±0.6)ng/mL vs(0.8±0.2)ng/mL,P<0.05)]and a higher level of IR(3.2±1.6 vs 1.9±1.5,P<0.05)were found in group A.Conclusion Increased endocrine disturbances and IR were found in the PCOS patients with HPRL.更多还原