【摘要】 目的 探讨尼古丁对腹部术后早期炎性肠梗阻的治疗作用。方法 将45例术后早期炎性肠梗阻的病人随机分为两组,对照组(26例)给予常规保守治疗加无尼古丁贴片;研究组(19例)在常规治疗基础上给予尼古丁贴片(21 mg/片),每日更换一次贴片,应用至治愈或最长至7 d。结果 研究组与对照组在腹痛缓解时间[(4.3±1.2)d与(5.3±1.4)d]、腹胀缓解时间[(3.7±1.5)d与(4.9±2.2)d]、肠鸣音恢复时间[(3.2±1.3)d与(4.4±1.7)d]、肛门排气时间[(4.5±1.2)d与(6.2±1.8)d]、治疗至出院时间[(7.3±2.6)d与(9.5±3.7)d]等方面相比均较短且差异有统计学意义(P<0.05);研究组与对照组的治愈率、总有效率相比,差异无统计学意义(P>0.05)。结论尼古丁用于腹部术后早期炎性肠梗阻的治疗中可促进症状缓解、加快梗阻解除,缩短疗程,但对于治愈率未有显著提高。更多还原

【Abstract】 Objective To evaluate the clinical application of nicotine in the treatment of early postoperative inflammatory small bowel obstruction(EPISBO).Methods Forty-five cases fell into two groups randomly:routine treatment group(26 cases) given intravenous infusion,total parenteral nutrition,gastrointestinal decompression,enema and placebo patch;observation group(19 cases)subject to nicotine patch(21 mg/day) for 7 days besides the routine treatment Treatment efficacy was compared between two groups.Results The average time of relief in abdominal distension[(3.7 ±1.5) days to(4.9±2.2) days]and pain[(4.3± 1.2) days to(5.3± 1.4) days],time of bowel sound reappearance[(3.2 ± 1.3) days to(4.4 ± 1.7) days],anal exhaust time[(4.5 ± 1.2) days to(6.2 ±1.8) days]and time of treatment[(7.3 ± 2.6) days to(9.5 ± 3.7) days]were apparently shortened in observation group as compared with those in routine treatment group(P<0.05).No significant differences were found in clinical curative rate(58%to 50%) and total effective rate(100%to 96%)between observation group and routine treatment group(P>0.05).Conclusions Nicotine application enhances treatment of EPISBO in symptom control and reduction in treatment period but reveals no improvement in the clinical curative rate.更多还原