【摘要】 目的研究应用糖皮质激素雾化吸入和嗅觉训练治疗感冒后嗅觉障碍的疗效及安全性。方法感冒后嗅觉障碍患者纳入研究。行T&T主观嗅觉测试、鼻窦CT扫描、嗅神经薄层扫描。治疗方案联合应用布地奈德雾化混悬剂(普米克令舒)雾化吸入(2 mg,1次/d,2周后减为1 mg)和嗅觉训练,疗程4周。治疗结束后复查T&T主观嗅觉测试。结果 24例完成治疗方案。其中女性21例,男性3例。平均年龄54岁(37~81岁),平均病史2.20个月(0.25~9个月)。其中完全失嗅21例,嗅觉减退3例。总体有效率为75%(18/24),其中治疗后嗅觉恢复正常4例(16.7%),嗅觉明显改善9例(37.5%),嗅觉改善5例(20.8%)。无效6例(25.0%)。无明显不良反应。结论初步研究结果显示糖皮质激素雾化和嗅觉训练能安全有效的治疗感冒后嗅觉障碍。更多还原

【Abstract】 OBJECTIVE To investigate the efficacy and safety of nebulizing glucocorticoid combined with olfactory training in the treatment of postviral olfactory dysfunction.METHODS Patients with postviral olfactory dysfunction were recruited in this study.All patients underwent T&T olfactory testing,sinonasal computer tomgraphy scanning,as well as magnetic resonance scanning of the olfactory pathway.Nebulizing glucocorticoid(pulmicort repulse) was inhaled once daily at the starting dose of 2 mg tapered to 1 mg after two weeks combined with olfactory training for 4 weeks.T&T olfactory testing were repeated after 4-week treatment.RESULTS Twenty four patients received teatment,with a mean age of 54 years old(range 37 to 81 years old),a mean olfactory dysfunction course of 2.20 months(range,0.25-9 months).Of whom,21 were anosmia,3 were hyposmia.After teatment,complete recovery were achieved in 4 patients(16.7%),obvious improvement in 9(37.5%),improvement in 5(20.8%),no improvement in 6(25.0%).No side effect and untoward effect were found.CONCLUSION The primmary outcomes suggest the efficacy and safety of nebulizing glucocorticoid combined with olfactory training in the treatment of postviral olfactory dysfunction.更多还原