Objective To evaluate the anticoagulant and antineoplastic activities of chemically modified low- molecular- weight heparin(LMWH). Methods LMWH obtained by splitting unfractionated heparin(UFH) with sodium periodate oxidation and sodium borohydride reduction was subjected to acetylation catalyzed by DCC and DMAP to produce acetylated LMWH(ALMWH). The anticoagulant activity of ALMWH was determined in mice, and its antiproliferative and anti- invasion activities was assessed in human breast cancer cells MDA- ...
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