【摘要】 动脉粥样硬化(atherosclerosis,AS)是一种以脂质在动脉壁上沉积并逐渐发展成粥样斑块的慢性炎症,而Treg细胞具有抗AS的作用,它通过细胞接触抑制和分泌IL-10、TGF-β等细胞因子来抑制效应T细胞的活化和增殖而发挥抗炎作用,抑制斑块的形成和发展,通过研究那些与Treg细胞增殖相关的因素如IL33/ST2、BMMSCs、ox-LDL、anti-CD3单抗、Myd-88等,为防治AS指出了一个新的方向。更多还原

【Abstract】 Atherosclerosis is a process of lipid deposition in the arterial wall with gradual plaque formation in association with chronic inflammation. Treg cells play a protective role in atherosclerosis. Through cell- to- cell contact inhibition and secretion of IL- 10,TGF- β and other cytokines,it suppresses effector T cell activation,proliferation and inhibits the formation and development of plaque. Therefore,studying the factors associated with Treg cell proliferation,such as IL33 /ST2,BM- MSCs,ox- LDL,anti- CD3 monoclonal antibody,Myd- 88,etc. will provide a new direction for the prevention and treatment of AS.更多还原