【摘要】 目的:探讨重组人表皮生长因子凝胶联合纳米银敷料对深Ⅱ度烧伤创面的疗效及安全性。方法:选择2011年1月~2013年6月我院收治的48例深Ⅱ度烧伤患者,随机选择相同深度的两个创面作为自身对照,分别采用单纯纳米银敷料(对照组)和纳米银敷料联合重组人表皮生长因子凝胶(治疗组)治疗,每组48例。观察两组病例创面愈合时间、不良反应及愈合质量。结果:治疗组创面愈合时间为(18.2±3.1)天,明显短于对照组(27.1±5.0)天,P<0.05;治疗组创面边缘炎症反应程度低于对照组,创面细菌培养菌落计数少于对照组,随访半年后全部愈合,愈合率(100%)高于对照组(85%)。结论:重组人表皮生长因子凝胶联合纳米银敷料治疗深Ⅱ度烧伤创面,能明显促进深Ⅱ度创面愈合,缩短愈合时间,降低创面炎症反应,提高愈合率。更多还原

【Abstract】 Objective: To investigate the effect of recombinant human epidermal growth factor(rh EGF) the curative effect and safety of gel combined with nano silver dressing in the treatment of deep Ⅱ degree burn wounds.Methods:48 cases of deep Ⅱ degree burn were selected from Jan 2011 to Jun 2013 in our hospital, two wounds were randomly selected the same depth as control group,were treated with single nanometer silver dressing(control group) the epidermis and nano silver dressing combined with recombinant human growth factor gel(treatment group) treatment,48 cases in each group.The two groups were observed and the wound healing time,adverse reactions and healing quality.Results:In treatment group,the wound healing time was(18.2±3.1) days,significantly shorter than the control group(27.1±5) days,P<0.05;the treatment group wound edge inflammation reaction degree lower than that of the control group,the wound bacteria culture colony count less than that in the control group,all healed after six months of follow-up,the rate of healing(100%) higher than that of the control group(85%).Conclusion: rh EGF gel with nanometer silver dressing in treating deep second degree burn wounds can obviously promote healing of deep Ⅱ degree burn wounds, shorten the healing time, reduce inflammation, improve the healing rate.更多还原