【摘要】 通过植入神经刺激系统进行深部脑刺激是治疗运动紊乱性疾病的有效手段,如帕金森疾病。本文采用各向异性四层真实头模型,包括:头皮、颅骨、脑脊液和大脑,应用有限元法对脑深部电刺激产生的电场分布进行了计算分析,并与各向同性头模型的结果进行了对比研究,分析了脑深部电刺激电场分布的影响因素。更多还原

【Abstract】 The deep brain stimulation(DBS) effect using implantable neuron-stimulation systems has become an important symptomatic therapy in movement disorders such as Parkinson’s disease. This study presents a head finite element model of deep brain stimulation to examine the electric field distribution. The electrical field distributions of DBS are analyzed with an anisotropic real head model and comparisons are carried out between the isotropic and anisotropic brain models. The head model using a geometrically accurate model includes four layers, i.e., scalp, skull, CSF, and brain. The purpose of this study is to assess the impacts on electric distribution by incorporating brain anisotropy in a forward numerical model for DBS.更多还原