过敏性紫癜患儿发生肾损害危险因素的Logistic回归分析

【摘要】 目的分析儿童过敏性紫癜(henoch-schonlein purpura,HSP)发生肾脏损害的危险因素。方法选取首次发病的HSP患儿168例,根据尿常规检测结果分为肾脏损害组55例和无肾脏损害组113例。对其临床资料进行回顾性分析。结果单因素分析显示2组患儿年龄、Ig E、D-二聚体、临床表型同时合并有关节症状和消化道症状、WBC、PLT、ESR、尿微量蛋白、尿球蛋白G方面比较,差异有统计学意义(P<0.05);在肾脏损害危险因素Logistic回归分析中年龄(P=0.005)、总Ig E(P=0.013)、WBC(P=0.002)、尿微量蛋白比较、ESR(P=0.001)。结论年龄、总Ig E、WBC、尿微量蛋白、ESR是HSP发生肾脏损害的危险因素,对于有上述因素的HSP患儿应加强观察。更多还原

【Abstract】 Objective To investigate the risk factors for renal damage with Henoch-Schonlein Purpura(HSP) in children. Methods Clinical data of 168 children of first episode HSP were retrospectively analyzed. Results Univariate ananlysis indicated that age,Ig E, D-dimer,The clinical phenotype combines the joint symptoms and gastrointestinal symptoms at the same time,WBC,PLT,ESR,urine microscale protein detection andurinary Ig G were significantly positive(P<0.05),the stepwise logistic regression analysis showed that age(P=0.005),Ig E(P=0.013), WBC(P=0.002), urine microscale protein detection(P=0.000)and ESR(P=0.001) were the risk factors for renal damage in children with HSP. Conclusion Age,Ig E,WBC, urine microscale protein detection and ESR were the risk factors for renal damage in children with HSP,patients who had these factors should reinforced observation.更多还原