【摘要】 目的探讨动态动脉硬化指数(AASI)、hs-CRP与原发性高血压患者冠心病之间的相关性。方法选用我院住院部高血压患者190例,根据24 h动态血压(ABPM)监测结果计算AASI,冠状动脉造影结果进行Gensini评分,根据评分结果:0-1分为非冠心病组(n=78),2-31分为轻、中度冠脉病变组(n=74),≥32分为重度冠脉病变组(n=38),采用单因素和Logistic回归分析与冠脉相关的危险因素。结果非冠心病组年龄、AASI、hs-CRP、24h HR、非杓型血压与冠心病组比较差异有统计学意义(P<0.05);在多因素logistic回归分析中,AASI和hs-CRP是影响冠心病发生的独立危险因素;3组AASI、hs-CRP组间比较差异有统计学意义(FAASI=35.9,P<0.05;Fhs-CRP=27.47,P<0.05)。重度冠脉病变组AASI、hs-CRP水平高于轻、中度组以及非冠心病组(P<0.05)。结论 AASI,hs-CRP对高血压患者出现冠脉病变及其严重程度有较好的预测价值。更多还原

【Abstract】 Objective To explore the correlation between the AASI,hs-CRP and coronary heart disease in primary hypertensive patients. Methods A total of 190 consecutive patients with primary hypertension which were hospitalized in our department were enrolled in this study. AASI was calculated based on the 24 h groups based on the ABPM,and all patients were divided into three groups according to the Gensini grade result. : non CHD group( 0-1 score,n = 78),mild lesion( 2-31 score,n = 74) and severe lesion( ≥32score,n = 38) group. Correlative risk factors were analyzed with One-ANOVA and multivariate logistic regression. Results There was statistical meaning comparing the age,AASI,hs-CRP,24 h HR,non-dipper type hypertension between the non-CHD group and CHD group( P<0. 05); and the AASI,hs-CRP was still risk factors contributing to the CHD; One-way ANOVA showed AASI,hs-CRP levels was significantly different among the three groups( FAASI= 35. 9,P <0. 05; Fhs-CRP= 27. 47,P < 0. 05),furthermore,Bonferroni multi-comparison demonstrated the level of the AASI,hs-CRP in the severe group was more higher than that in the non-CHD group and mild group( P<0. 05). Conclusion AASI and hs-CRP is closely related to the CHD and the severity of coronary artery stenosis.更多还原