【摘要】 目的观察奥美拉唑联合中药口服综合疗法治疗十二指肠溃疡的临床疗效。方法采用随机数字表法将70例十二指肠溃疡患者分为治疗组和对照组,各35例。治疗组采用西药配合中药(柴胡、党参、茯苓、白术,1剂/d,早晚分服)综合疗法口服,对照组仅服用奥美拉唑胶囊(10 mg/d),观察治疗后第1,3个月患者主要症状积分、中医证候疗效及胃镜下疗效。结果 2组治疗后第1个月,主要症状上腹痛、嗳气、反酸、胸骨后烧灼感积分与治疗前比较,具有下降趋势(P<0.05,P<0.01),且治疗组优于对照组(P<0.05);上腹胀积分仅治疗组治疗前后有统计学意义(P<0.05)。随访第3个月,2组上腹痛、嗳气分值与治疗前比较明显降低(P<0.05,P<0.01),且治疗组改善情况要优于对照组(P<0.05)。治疗组证候疗效总有效率为88.57%,对照组77.14%,2组比较,具有统计学意义(P<0.05)。治疗组胃镜下疗效总有效率为77.14%,对照组为60.00%,2组比较,具有统计学意义(P<0.05)。结论奥美拉唑胶囊配合中药口服疗法可明显降低十二指肠溃疡的主要症状积分,提升中医证候疗效及改善胃镜下表现。更多还原

【Abstract】 Objective To observe the clinical curative effect analysis of Omeprazole with oral Chinese medicine comprehensive therapy in the treatment of duodenal ulcer. Methods 70 cases selected from the spleen and stomach disease outpatient and hospitalized patients,were randomly divided into two groups,35 cases in the treatment group,and35 cases in the control group. Treatment group were treated with western medicine combined with the traditional Chinese medicine( radix bupleuri,dangshen,poria cocos,atractylodes,1 dose / d,morning and evening) comprehensive therapy,the control group was given omeprazole capsules( 10 mg / d),respectively observe the patients’ symptoms after first,third month,before and after treatment,explore the integral of TCM curative effect under gastroscope. Results The main symptom integral change: after first month treatment,upper abdominal pain,belching,acid regurgitation,retrosternal burning sensation is found in the two groups before and after treatment,the integral trend of decline,with statistical difference( P < 0. 05,0. 01); in addition,reduce abdominal distension in the treatment group compared before and after the score,the difference was statistically significant( P < 0. 05). For upper abdominal pain,belching,integral retrosternal burning sensation,treatment group had significantly decreased compared with the control,with statistical difference( P < 0. 05). At follow-up third months in treatment group,the abdominal pain,belching score is significantly reduced( P < 0. 05,P < 0. 01); the control group in which two symptoms have improved( P < 0. 05),but the process of follow-up,the treatment group and control group,can be found in the improvement in the treatment group to better than the control group( P < 0. 05). Evaluation of the overall effect of syndrome: the total effective rate was 88.57% in the treatment group,77. 14% in control group; the two groups had significant difference( P < 0. 05). The endoscopic curative effect comparison,the total effective rate of treatment group was 77. 14%,total effective rate of the control group was 60. 00%,and total effective rate was statistically difference between the two groups( P < 0. 05).Conclusion Omeprazole capsules with oral medicine therapy can obviously reduce the main symptom integral of duodenal ulcer,ascending syndromes curative effect and improve the performance under gastroscope.更多还原