【摘要】 目的研究甲状腺乳头状癌中FAK和MMP-9蛋白的表达及临床意义。方法采用免疫组织化学技术SP法检测60例人甲状腺乳头状癌组织和癌旁组织标本中FAK和MMP-9蛋白的表达。结果 1)人甲状腺乳头状癌组织组中FAK和MMP-9蛋白的阳性表达率为75%、70.0%,而癌旁组织中FAK和MMP-9蛋白的阳性表达率为26.7%、11.7%,癌组织组中FAK和MMP-9阳性率明显高于癌旁组织组,两组差别在统计学上有明显差异(P<0.05)。2)有淋巴结转移甲状腺乳头状癌组中的FAK和MMP-9的阳性表达,明显高于无淋巴结转移组,在统计学上有明显差异(P<0.05)。结论 FAK和MMP-9在人甲状腺乳头状癌组织中均呈高表达,参与了人甲状腺乳头状癌的发生、发展及浸润、转移。更多还原

【Abstract】 Objective To study the role of FAK and MMP-9 expressions in the development of papillary thyroid carcinoma. Methods Expressions of FAK and MMP-9 were detected by SP immunohistochemical technique in 60 pairs of papillary thyroid carcinoma and the corresponding non-tumor tissues. Results 1) The Results show that the positive rates of FAK and MMP-9 protein in papillary thyroid carcinoma are 75%(45 /60),70. 0%(42 /60) respectively,and the positive rates of FAK and MMP-9 protein in the corresponding non-tumor tissues are 26. 7%(15 /60) and 11. 7%(18 /60) respectively,and FAK and MMP-9 expression in papillary thyroid carcinoma are higher than the corresponding non-tumor tissues( P <0. 05). 2) FAK and MMP-9 protein in papillary thyroid carcinoma with lymph node metastasis and are higher than those without metastasis( P < 0. 05). Conclusion The high expressions of FAK and MMP-9protein suggest that they may play an important role in the development of papillary thyroid carcinoma. It prompts tumor invasion and metastasis.更多还原