【摘要】 目的本研究通过检测正常早孕及不明原因反复自然流产(URSA)患者子宫蜕膜中髓样树突状细胞(MDC)及浆细胞样树突状细胞(PDC)的水平,探讨树突状细胞(DC)亚群在URSA中的作用。方法选取URSA患者(n=22)作为URSA组,正常早孕妇女(n=20)作为对照组,采用流式细胞技术检测其蜕膜中MDC及PDC亚群的水平,比较其数量和比值的变化。结果URSA组与对照组比较,蜕膜中DC、MDC、MDC/PDC值的水平均显著增高(P<0.05)。结论 URSA患者蜕膜中DC、MDC的水平及MDC/PDC值明显增加,可能是URSA发病的免疫因素之一。更多还原

【Abstract】 Objective To explore the changes of the subsets of dendritie cells(DC)in normal pregnant women and patients with unexplained early spontaneous abortion.Methods Twenty normal pregnant women and 21 unexplained early spontaneous abortion patients were included in this study.The DC were stained with monoclonal antibodies and estimated by the flow cytometric method.Comparson of the numbers and subsets of DC in the decidua were performed between the two groups.Results The level of DC and MDC,MDC/PDC ratio in the decidua of spontaneous abortion patients were higher than the normal pregnant women(P<0.05).Conclusion The percentage of DC and myeloid DC and the MDC/PDC ratio in the unexplained early spontaneous abortion patients is significantly higher than that in the normal pregnant women.It may contribute to the spontaneous abortion.更多还原