【摘要】 目的研究银丹心脑通软胶囊对2型糖尿病氧化应激及血管内皮功能的影响。方法 86例2型糖尿病患者按照随机数字表法分成常规降糖治疗组(常规组,n=40)和银丹心脑通软胶囊治疗组(银丹心脑通组,n=46)。常规组患者在控制饮食、运动等基础上给予降糖治疗使血糖连续达标12周,银丹心脑通组在常规治疗血糖达标基础上加用银丹心脑通软胶囊(每次1.2g,每日3次)连续治疗12周。检测两组患者治疗前后血脂、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、内皮素(ET)等相关因素变化,应用超声检测肱动脉血流介导的内皮依赖性舒张功能(FMD)和非内皮依赖性血管舒张功能(NMD)。结果治疗12周后两组患者血浆总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、MDA、ET较治疗前均有明显下降,高密度脂蛋白胆固醇(HDL-C)、SOD、NO、FMD则较治疗前升高(P<0.05);而且银丹心脑通组治疗后上述各项指标与常规组治疗后比较也有显著变化(P<0.05)。结论银丹心脑通软胶囊可下调2型糖尿病氧化应激,调节糖尿病脂代谢异常,明显改善损伤的血管内皮功能。更多还原

【Abstract】 Objective To investigate the effects of Yindan Xinnaotong Soft Capsule on oxidative stress and vascular endothelial function in the patients with type 2diabetes mellitus(T2DM).Methods A total of 86 patients with T2 DM were randomly divided into the routine glucose-reducing group(routine group,40cases)and the Yindan Xinnaotong Soft Capsule group(Yindan Xinnaotong group,46cases).On the basis of diet control and exercise,the routine group was given the glucose-reducing therapy for blood glucose reaching the standard for 12 successive weeks,while on the basis of blood glucose reaching the standard by the routine therapy,the Yindan Xinnaotong group was added with Yindan Xinnaotong Soft Capsule,1.2g per time,3times daily for 12 successive weeks.The changes of blood lipids,MDA,SOD,NO and ET were determined before treatment and after 12-week treatment.The flow mediated endothelium-dependent diastolic function(FMD)and non-flow mediated endothelium-dependent diastolic function(NMD)in brachial artery were simultaneously detected using ultrasonography.Results After 12 weeks of treatment,the levels of TC,TG,LDL-C,MDA and ET in the two group were obviously decreased compared with before treatment,the levels of HDL-C,SOD,NO and FMD in both groups were increased(P<0.05);moreover the above indexes after treatment in the Yindan Xinnaotong group had significant changes compared with the routine group(P<0.05).Conclusion Yindan Xinnaotong Soft Capsule can down-regulate oxidative stress and regulate the lipid metabolic abnormality and obviously improve the injured vascular endothelial function in T2 DM.更多还原