【摘要】 目的探讨不同类型心房颤动(房颤)患者血浆脂联素(APN)和N末端B型脑利钠肽原(NT-proBNP)的变化。方法将234例研究对象分为4组:窦性心律组70例、阵发性房颤组52例、永久性房颤组62例和对照组50例(健康体检者),采用酶联免疫吸附试验测定血浆脂联素水平,并检测NT-proBNP水平。结果阵发性房颤组、永久性房颤组患者NT-proBNP显著升高,与对照组和窦性心律组比较,差异有统计学意义(P<0.05);对照组与窦性心律组比较差异无统计学意义(P>0.05);与阵发性房颤组比较,永久性房颤组NT-proBNP明显升高(P<0.05)。与对照组比较,窦性心律组脂联素水平明显降低(P<0.05),与对照组和窦性心律组比较,阵发性房颤组和永久性房颤组患者脂联素水平均显著升高(P<0.05),与阵发性房颤组比,永久性房颤组脂联素水平明显升高(P<0.05)。结论脂联素的水平可能与永久性房颤的反复发生有关。更多还原

【Abstract】 Objective To investigate the changes of plasma adiponectin and N-terminal pro-brain natriuretic peptide(NTproBNP)levels in the patients with different types of atrial fibrillation(Af).Methods Two hundred and thirty-four research subjects were divided into 4groups:sinus rhythm group(n=70),paroxysmal Af group(n=52),permanent Af group(n=62)and control group(n=50).The plasma adiponectin level was measured by the enzyme-linked immunosorbent assay(ELISA)and the NT-proBNP level was detected by chemiluminescence.4groups were comparable in age,gender,body mass index and basic diseases.Results The NT-proBNP level in the paroxysmal Af group and the permanent Af group was significantly increased compared with the sinus rhythm group and the control group,the difference was statistically significant(P<0.05),but the difference between the sinus rhythm group and the control group had no statistical significance(P>0.05).The NT-proBNP level in the permanent Af group was significantly increased compared with the paroxysmal Af group(P<0.05).Compared with control group,the adiponectin level in the sinus rhythm group was significantly decreased(P<0.05),which in the paroxysmal Af group and the permanent Af group was significantly increased compared with the sinus rhythm group and the control group,the difference was statistically significant(P<0.05).The adiponectin level in the permanent Af group was significantly increased compared with the paroxysmal Af group(P<0.05).Conclusion The adiponectin level could be related with the repeated occurrence of permanent Af.更多还原