【摘要】 为了增强海藻酸钠凝胶的稳定性以及对药物的缓释效果,将海藻酸钠用聚乙二醇(PEG200)交联,在水溶液中用对甲苯磺酸催化、经过酯化反应合成了共价交联的海藻酸钠凝胶;通过红外光谱、热重分析和X-射线分析对产物进行了表征。与钙离子交联的海藻酸钠凝胶相比,共价交联海藻酸凝胶在仿生体液中结构稳定,在模拟体液中完全降解时间持续到60天。凝胶对牛血清白蛋白的载药率达到11.5%,显示出明显的缓释效应和pH响应性能,具有作为pH控释和缓释药物载体的应用前景。更多还原

【Abstract】 In order to enhance the stability of alginate hydrogel in salt solutions and to improve sustained drug release,covalently cross-linked alginic acid gel was synthesized through an esterification of sodium alginate with polyethylene glycol(PEG200)in an aqueous solution,using p-toluenesulfonic acid as a catalyst.Products were confirmed by infrared spectroscopy,thermal analysis and X-ray diffraction analysis.Compared with ionic crosslinked calcium alginate gel,the covalently crosslinked alginic acid gels show a stable structure in bionic body fluids,and the complete degradation time in the bionic body fluids sustains for 60 days.Gels are used as drug vehicles for loading of hydrophilic bovine serum albumin.It is observed that the covalently crosslinked alginic acid gel displays loading rate as high as 11.5%,and obvious sustained slow-release and pH responsiveness.The covalently cross-linked alginic acid gels have application prospects as drug carriers for pH controlled and sustained release.更多还原